| 9/2/2010 | Murray State 10 @ Kent State Golden Flashes 41 | |
| 9/11/2010 | SE Missouri State Redhawks 30 @ Murray State 17 | † |
| 9/18/2010 | Murray State 20 @ Central Arkansas Bears 21 | |
| 9/25/2010 | Tennessee-Martin Skyhawks 16 @ Murray State 52 | † |
| 10/2/2010 | Murray State 34 @ Jacksonville State Gamecocks 40 | † |
| 10/9/2010 | Missouri State Bears 59 @ Murray State 72 | |
| 10/23/2010 | Murray State 38 @ Eastern Illinois Panthers 28 | † |
| 10/30/2010 | Murray State 21 @ Eastern Kentucky Colonels 28 | † |
| 11/6/2010 | Tennessee Tech Golden Eagles 13 @ Murray State 44 | † |
| 11/13/2010 | Murray State 61 @ Austin Peay Governers 35 | † |
| 11/20/2010 | Tennessee State Tigers 23 @ Murray State 28 | † |