| 9/2/2010 | West Chester Golden Rams 0 @ Delaware 31 | |
| 9/11/2010 | South Dakota State Jackrabbits 3 @ Delaware 26 | |
| 9/18/2010 | Duquesne Dukes 6 @ Delaware 30 | |
| 9/25/2010 | Delaware 34 @ Richmond Spiders 13 | † |
| 10/2/2010 | Delaware 13 @ James Madison Dukes 10 | † |
| 10/9/2010 | Maine Black Bears 7 @ Delaware 26 | † |
| 10/16/2010 | Rhode Island Rams 17 @ Delaware 24 | † |
| 10/23/2010 | Delaware 16 @ William & Mary Tribe 17 | † |
| 11/6/2010 | Towson Tigers 0 @ Delaware 48 | † |
| 11/13/2010 | Delaware 45 @ Massachusetts Minutemen 27 | † |
| 11/20/2010 | Villanova Wildcats 28 @ Delaware 21 1OT | † |
| 12/4/2010 | Lehigh Mountain Hawks 20 @ Delaware 42 | |
| 12/10/2010 | New Hampshire Wildcats 3 @ Delaware 16 | † |
| 12/18/2010 | Georgia Southern Eagles 10 @ Delaware 27 (FCS Semifinals) | |
| 1/7/2011 | Delaware 19 vs Eastern Washington Eagles 20 (Frisco TX - FCS Championship) |