| 9/3/2010 | Eastern Kentucky 9 @ Missouri State Bears 31 | |
| 9/11/2010 | Eastern Kentucky 13 @ Louisville Cardinals 23 | |
| 9/18/2010 | Eastern Kentucky 24 @ Chattanooga Moccasins 42 | |
| 10/2/2010 | Kentucky State Thorobreds 7 @ Eastern Kentucky 58 | |
| 10/9/2010 | Eastern Illinois Panthers 7 @ Eastern Kentucky 35 | † |
| 10/16/2010 | Eastern Kentucky 7 @ Tennessee-Martin Skyhawks 10 | † |
| 10/23/2010 | Eastern Kentucky 21 @ SE Missouri State Redhawks 40 | † |
| 10/30/2010 | Murray State Racers 21 @ Eastern Kentucky 28 | † |
| 11/6/2010 | Jacksonville State Gamecocks 37 @ Eastern Kentucky 49 | † |
| 11/13/2010 | Eastern Kentucky 42 @ Tennessee Tech Golden Eagles 29 | † |
| 11/20/2010 | Austin Peay Governers 3 @ Eastern Kentucky 17 | † |