| 9/4/2010 | Eastern Illinois 7 @ Iowa Hawkeyes 37 | |
| 9/11/2010 | Central Arkansas Bears 37 @ Eastern Illinois 7 | |
| 9/18/2010 | Eastern Illinois 10 @ Tennessee-Martin Skyhawks 20 | † |
| 9/25/2010 | Jacksonville State Gamecocks 28 @ Eastern Illinois 23 | † |
| 10/2/2010 | SE Missouri State Redhawks 28 @ Eastern Illinois 13 | † |
| 10/9/2010 | Eastern Illinois 7 @ Eastern Kentucky Colonels 35 | † |
| 10/16/2010 | Eastern Illinois 20 @ Tennessee Tech Golden Eagles 34 | † |
| 10/23/2010 | Murray State Racers 38 @ Eastern Illinois 28 | † |
| 10/30/2010 | Austin Peay Governers 10 @ Eastern Illinois 28 | † |
| 11/6/2010 | Eastern Illinois 31 @ Tennessee State Tigers 28 1OT | † |
| 11/13/2010 | Eastern Illinois 23 @ Illinois State Redbirds 27 |