| 9/2/2010 | Quincy 7 @ Southern Illinois Salukis 70 | |
| 9/11/2010 | Quincy 0 @ Walsh Cavaliers 38 | † |
| 9/18/2010 | Quincy 58 @ William Penn Statesmen 67 | † |
| 9/25/2010 | St Xavier Cougars 45 @ Quincy 14 | † |
| 10/2/2010 | Quincy 22 @ Indiana State Sycamores 56 | |
| 10/9/2010 | Quincy 14 @ Grand View Vikings 41 | † |
| 10/16/2010 | Iowa Wesleyan Tigers 62 @ Quincy 50 | † |
| 10/23/2010 | Quincy 7 @ Saint Ambrose Bees 44 | † |
| 10/30/2010 | McKendree Bearcats 50 @ Quincy 21 | † |
| 11/6/2010 | Quincy 3 @ St Francis IL Fighting Saints 35 | † |
| 11/13/2010 | Waldorf Warriors 21 @ Quincy 17 | † |