| 9/2/2010 | Northern Illinois Huskies 10 @ Iowa State 27 | |
| 9/11/2010 | Iowa State 7 @ Iowa Hawkeyes 35 | |
| 9/18/2010 | Iowa State 20 vs Kansas State Wildcats 27 (Kansas City MO) | † |
| 9/25/2010 | Northern Iowa Panthers 0 @ Iowa State 27 | |
| 10/2/2010 | Texas Tech Red Raiders 38 @ Iowa State 52 | † |
| 10/9/2010 | Utah Utes 68 @ Iowa State 27 | |
| 10/16/2010 | Iowa State 0 @ Oklahoma Sooners 52 | † |
| 10/23/2010 | Iowa State 28 @ Texas Longhorns 21 | † |
| 10/30/2010 | Kansas Jayhawks 16 @ Iowa State 28 | † |
| 11/6/2010 | Nebraska Cornhuskers 31 @ Iowa State 30 1OT | † |
| 11/13/2010 | Iowa State 14 @ Colorado Buffaloes 34 | † |
| 11/20/2010 | Missouri Tigers 14 @ Iowa State 0 | † |