| 9/4/2010 | Youngstown State Penguins 14 @ Penn State 44 | |
| 9/11/2010 | Penn State 3 @ Alabama Crimson Tide 24 | |
| 9/18/2010 | Kent State Golden Flashes 0 @ Penn State 24 | |
| 9/25/2010 | Temple Owls 13 @ Penn State 22 | |
| 10/2/2010 | Penn State 3 @ Iowa Hawkeyes 24 | † |
| 10/9/2010 | Illinois Fighting Illini 33 @ Penn State 13 | † |
| 10/23/2010 | Penn State 33 @ Minnesota Golden Gophers 21 | † |
| 10/30/2010 | Michigan Wolverines 31 @ Penn State 41 | † |
| 11/6/2010 | Northwestern Wildcats 21 @ Penn State 35 | † |
| 11/13/2010 | Penn State 14 @ Ohio State Buckeyes 38 | † |
| 11/20/2010 | Penn State 41 vs Indiana Hoosiers 24 (Landover MD) | † |
| 11/27/2010 | Michigan State Spartans 28 @ Penn State 22 | † |
| 1/1/2011 | Florida Gators 37 vs Penn State 24 (Tampa - Outback Bowl) |