| 9/4/2010 | Butler 29 @ Albion Britons 13 | |
| 9/11/2010 | Butler 7 @ Youngstown State Penguins 31 | |
| 9/18/2010 | Taylor Trojans 20 @ Butler 28 | |
| 9/25/2010 | Butler 0 @ San Diego Toreros 24 | † |
| 10/2/2010 | Campbell Camels 27 @ Butler 10 | † |
| 10/9/2010 | Butler 24 @ Davidson Wildcats 8 | † |
| 10/16/2010 | Dayton Flyers 33 @ Butler 13 | † |
| 10/23/2010 | Morehead State Eagles 21 @ Butler 20 | † |
| 10/30/2010 | Butler 48 @ Valparaiso Crusaders 0 | † |
| 11/6/2010 | Jacksonville Dolphins 24 @ Butler 16 | † |
| 11/13/2010 | Butler 7 @ Drake Bulldogs 10 | † |