| 8/28/2010 | Central Missouri 60 @ Southwest Baptist Bearcats 13 | |
| 9/2/2010 | Central Missouri 54 @ Illinois State Redbirds 55 | |
| 9/11/2010 | Emporia State Hornets 13 @ Central Missouri 31 | † |
| 9/18/2010 | Central Missouri 37 @ Pittsburg State Gorillas 20 | † |
| 9/25/2010 | Washburn Ichabods 45 @ Central Missouri 55 | † |
| 10/2/2010 | Central Missouri 38 @ Truman State Bulldogs 14 | † |
| 10/9/2010 | Central Missouri 30 @ Fort Hays State Tigers 27 | † |
| 10/16/2010 | Missouri Western Griffons 21 @ Central Missouri 43 | † |
| 10/23/2010 | Nebraska-Omaha Mavericks 31 @ Central Missouri 34 | † |
| 10/30/2010 | Central Missouri 34 @ Missouri Southern Lions 21 | † |
| 11/6/2010 | Northwest Missouri State Bearcats 17 @ Central Missouri 16 | † |
| 11/20/2010 | West Texas A&M Buffaloes 35 @ Central Missouri 55 | |
| 11/27/2010 | Central Missouri 55 @ Abilene Christian Wildcats 41 | |
| 12/4/2010 | Central Missouri 20 @ Northwest Missouri State Bearcats 37 | † |