| 9/2/2010 | SE Missouri State 10 @ Ball State Cardinals 27 | |
| 9/11/2010 | SE Missouri State 30 @ Murray State Racers 17 | † |
| 9/18/2010 | SE Missouri State 24 @ Southern Illinois Salukis 21 | |
| 9/25/2010 | Tennessee Tech Golden Eagles 21 @ SE Missouri State 23 | † |
| 10/2/2010 | SE Missouri State 28 @ Eastern Illinois Panthers 13 | † |
| 10/9/2010 | Tennessee State Tigers 17 @ SE Missouri State 19 | † |
| 10/16/2010 | SE Missouri State 41 @ Austin Peay Governers 24 | † |
| 10/23/2010 | Eastern Kentucky Colonels 21 @ SE Missouri State 40 | † |
| 10/30/2010 | Tennessee-Martin Skyhawks 17 @ SE Missouri State 24 | † |
| 11/6/2010 | Southwest Baptist Bearcats 14 @ SE Missouri State 40 | |
| 11/13/2010 | SE Missouri State 27 @ Jacksonville State Gamecocks 29 | † |
| 12/4/2010 | SE Missouri State 17 @ Eastern Washington Eagles 37 |