| 9/4/2010 | Western Kentucky Hilltoppers 10 @ Nebraska 49 | |
| 9/11/2010 | Idaho Vandals 17 @ Nebraska 38 | |
| 9/18/2010 | Nebraska 56 @ Washington Huskies 21 | |
| 9/25/2010 | South Dakota State Jackrabbits 3 @ Nebraska 17 | |
| 10/7/2010 | Nebraska 48 @ Kansas State Wildcats 13 | † |
| 10/16/2010 | Texas Longhorns 20 @ Nebraska 13 | † |
| 10/23/2010 | Nebraska 51 @ Oklahoma State Cowboys 41 | † |
| 10/30/2010 | Missouri Tigers 17 @ Nebraska 31 | † |
| 11/6/2010 | Nebraska 31 @ Iowa State Cyclones 30 1OT | † |
| 11/13/2010 | Kansas Jayhawks 3 @ Nebraska 20 | † |
| 11/20/2010 | Nebraska 6 @ Texas A&M Aggies 9 | † |
| 11/26/2010 | Colorado Buffaloes 17 @ Nebraska 45 | † |
| 12/4/2010 | Nebraska 20 vs Oklahoma Sooners 23 (Arlington TX-Big 12 Championship ) | † |
| 12/30/2010 | Nebraska 7 vs Washington Huskies 19 (San Diego - Holiday Bowl) |