| 9/4/2010 | Purdue 12 @ Notre Dame Fighting Irish 23 | |
| 9/11/2010 | Western Illinois Leathernecks 21 @ Purdue 31 | |
| 9/18/2010 | Ball State Cardinals 13 @ Purdue 24 | |
| 9/25/2010 | Toledo Rockets 31 @ Purdue 20 | |
| 10/9/2010 | Purdue 20 @ Northwestern Wildcats 17 | † |
| 10/16/2010 | Minnesota Golden Gophers 17 @ Purdue 28 | † |
| 10/23/2010 | Purdue 0 @ Ohio State Buckeyes 49 | † |
| 10/30/2010 | Purdue 10 @ Illinois Fighting Illini 44 | † |
| 11/6/2010 | Wisconsin Badgers 34 @ Purdue 13 | † |
| 11/13/2010 | Michigan Wolverines 27 @ Purdue 16 | † |
| 11/20/2010 | Purdue 31 @ Michigan State Spartans 35 | † |
| 11/27/2010 | Indiana Hoosiers 34 @ Purdue 31 1OT | † |