| 9/2/2010 | Elizabeth City State @ Central Arkansas | |
| 9/2/2010 | Southeastern Louisiana @ Tulane | |
| 9/4/2010 | Northwestern State @ Air Force | |
| 9/4/2010 | Sam Houston @ Baylor | |
| 9/4/2010 | Texas State @ Houston | |
| 9/4/2010 | Lamar @ McNeese State | † |
| 9/4/2010 | Nicholls State @ San Diego State | |
| 9/4/2010 | Stephen F. Austin @ Texas A&M | |
| 9/11/2010 | Central Arkansas @ Eastern Illinois | |
| 9/11/2010 | Webber International @ Lamar | |
| 9/11/2010 | McNeese State @ Missouri | |
| 9/11/2010 | Samford @ Northwestern State | |
| 9/11/2010 | Tennessee-Martin @ Southeastern Louisiana | |
| 9/11/2010 | Albany NY @ Stephen F. Austin | |
| 9/11/2010 | Southern Arkansas @ Texas State | |
| 9/11/2010 | Nicholls State @ Western Michigan | |
| 9/18/2010 | Murray State @ Central Arkansas | |
| 9/18/2010 | Stephen F. Austin @ Northern Iowa | |
| 9/18/2010 | Tarleton State @ Northwestern State | |
| 9/18/2010 | Lamar @ Southeastern Louisiana | † |
| 9/18/2010 | Nicholls State @ South Alabama | |
| 9/18/2010 | Cal Poly @ Texas State | |
| 9/18/2010 | Sam Houston @ Western Illinois | |
| 9/25/2010 | Southeastern Louisiana @ UL Monroe | |
| 9/25/2010 | Cal Poly @ McNeese State | |
| 9/25/2010 | Bacone @ Nicholls State | |
| 9/25/2010 | Northwestern State @ North Dakota | |
| 9/25/2010 | Gardner-Webb @ Sam Houston | |
| 9/25/2010 | Lamar @ Stephen F. Austin | † |
| 9/25/2010 | Southern Utah @ Texas State | |
| 9/25/2010 | Central Arkansas @ Tulsa | |
| 10/2/2010 | Sam Houston @ Lamar | † |
| 10/2/2010 | McNeese State @ Northwestern State | † |
| 10/9/2010 | Northwestern State @ Central Arkansas | † |
| 10/9/2010 | Langston @ Lamar | |
| 10/9/2010 | Stephen F. Austin @ McNeese State | † |
| 10/9/2010 | Sam Houston @ Nicholls State | † |
| 10/9/2010 | Texas State @ Southeastern Louisiana | † |
| 10/16/2010 | South Alabama @ Lamar | |
| 10/16/2010 | McNeese State @ LSU | |
| 10/16/2010 | Southeastern Louisiana @ Sam Houston | † |
| 10/16/2010 | Central Arkansas @ Stephen F. Austin | † |
| 10/16/2010 | Nicholls State @ Texas State | † |
| 10/23/2010 | Central Arkansas @ Nicholls State | † |
| 10/23/2010 | Stephen F. Austin vs Sam Houston | † |
| 10/23/2010 | McNeese State @ Southeastern Louisiana | † |
| 10/23/2010 | Northwestern State @ Texas State | † |
| 10/30/2010 | Southeastern Louisiana @ Central Arkansas | † |
| 10/30/2010 | Nicholls State @ McNeese State | † |
| 10/30/2010 | Lamar @ North Dakota | |
| 10/30/2010 | Sam Houston @ Northwestern State | † |
| 10/30/2010 | Texas State @ Stephen F. Austin | † |
| 11/6/2010 | Lamar @ Georgia State | |
| 11/6/2010 | Stephen F. Austin @ Nicholls State | † |
| 11/6/2010 | McNeese State @ Sam Houston | † |
| 11/6/2010 | Northwestern State @ Southeastern Louisiana | † |
| 11/6/2010 | Central Arkansas @ Texas State | † |
| 11/13/2010 | Sam Houston @ Central Arkansas | † |
| 11/13/2010 | South Dakota @ Lamar | |
| 11/13/2010 | Texas State @ McNeese State | † |
| 11/13/2010 | Nicholls State @ Northwestern State | † |
| 11/13/2010 | Southeastern Louisiana @ Stephen F. Austin | † |
| 11/18/2010 | Southeastern Louisiana @ Nicholls State | † |
| 11/20/2010 | McNeese State @ Central Arkansas | † |
| 11/20/2010 | Panhandle State @ Lamar | |
| 11/20/2010 | Texas State @ Sam Houston | † |
| 11/20/2010 | Northwestern State @ Stephen F. Austin | † |