| 8/28/2010 | Johnson C Smith Golden Bulls 27 @ Elizabeth City State 45 | † |
| 9/2/2010 | Elizabeth City State 20 @ Central Arkansas Bears 47 | |
| 9/18/2010 | Elizabeth City State 38 vs Fayetteville State Broncos 26 (Rocky Mount NC) | † |
| 9/25/2010 | Shaw Bears 31 @ Elizabeth City State 28 | † |
| 10/2/2010 | St Paul's Fighting Tigers 12 @ Elizabeth City State 30 | † |
| 10/9/2010 | Virginia Union Panthers 14 @ Elizabeth City State 17 | † |
| 10/14/2010 | Elizabeth City State 10 @ Virginia State Trojans 15 | † |
| 10/23/2010 | Elizabeth City State 12 @ Bowie State Bulldogs 20 | † |
| 10/30/2010 | Chowan Braves 7 @ Elizabeth City State 55 | † |
| 11/6/2010 | Elizabeth City State 36 @ Lincoln PA Lions 6 | † |