| 9/4/2010 | Southern Utah 20 @ Wyoming Cowboys 28 | |
| 9/11/2010 | San Diego Toreros 3 @ Southern Utah 32 | |
| 9/18/2010 | Southern Utah 11 @ San Jose State Spartans 16 | |
| 9/25/2010 | Southern Utah 28 @ Texas State Bobcats 42 | |
| 10/2/2010 | Northern Arizona Lumberjacks 26 @ Southern Utah 23 | |
| 10/9/2010 | Southern Utah 31 @ North Dakota Sioux 21 | † |
| 10/16/2010 | Cal Poly Mustangs 7 @ Southern Utah 20 | † |
| 10/23/2010 | South Dakota Coyotes 13 @ Southern Utah 31 | † |
| 10/30/2010 | Southern Utah 55 @ UC Davis Aggies 24 | † |
| 11/6/2010 | Dixie State Rebels 0 @ Southern Utah 52 | |
| 11/13/2010 | Southern Utah 24 @ Eastern Washington Eagles 31 |