| 9/2/2010 | Northeastern State Riverhawks 31 @ Tarleton State 23 | † |
| 9/11/2010 | Tarleton State 21 @ Central Oklahoma Bronchos 37 | † |
| 9/18/2010 | Tarleton State 14 @ Northwestern State Demons 17 | |
| 9/25/2010 | Tarleton State 3 @ Abilene Christian Wildcats 65 | † |
| 10/2/2010 | Angelo State Rams 34 @ Tarleton State 37 | † |
| 10/9/2010 | Tarleton State 17 @ West Texas A&M Buffaloes 48 | † |
| 10/16/2010 | Tarleton State 34 @ Texas A&M-Commerce Lions 31 | † |
| 10/23/2010 | Texas A&M-Kingsville Javelinas 13 @ Tarleton State 10 | † |
| 10/30/2010 | Tarleton State 26 @ Midwestern State Mustangs 31 | † |
| 11/6/2010 | Incarnate Word Cardinals 27 @ Tarleton State 41 | † |
| 11/13/2010 | Eastern New Mexico Greyhounds 35 @ Tarleton State 10 | † |