| 9/4/2010 | Tennessee-Martin 0 @ Tennessee Volunteers 50 | |
| 9/11/2010 | Tennessee-Martin 10 @ Southeastern Louisiana Lions 24 | |
| 9/18/2010 | Eastern Illinois Panthers 10 @ Tennessee-Martin 20 | † |
| 9/25/2010 | Tennessee-Martin 16 @ Murray State Racers 52 | † |
| 9/30/2010 | Tennessee-Martin 27 @ Tennessee Tech Golden Eagles 24 | † |
| 10/9/2010 | Jacksonville State Gamecocks 30 @ Tennessee-Martin 20 | † |
| 10/16/2010 | Eastern Kentucky Colonels 7 @ Tennessee-Martin 10 | † |
| 10/21/2010 | Lambuth Eagles 21 @ Tennessee-Martin 52 | |
| 10/30/2010 | Tennessee-Martin 17 @ SE Missouri State Redhawks 24 | † |
| 11/6/2010 | Tennessee-Martin 28 @ Austin Peay Governers 12 | † |
| 11/13/2010 | Tennessee State Tigers 0 @ Tennessee-Martin 37 | † |