| 8/28/2010 | Colorado State -Pueblo ThunderWolves 23 @ Panhandle State 14 | |
| 9/4/2010 | Panhandle State 32 @ Southwestern Moundbuilders 27 | |
| 9/11/2010 | New Mexico Highlands Cowboys 6 @ Panhandle State 14 | |
| 9/18/2010 | Panhandle State 22 @ Lincoln MO Blue Tigers 23 | † |
| 9/25/2010 | Langston Lions 30 @ Panhandle State 14 | |
| 10/16/2010 | Texas College Steers 14 @ Panhandle State 23 | |
| 10/23/2010 | Southwestern Assemblies of God Lions 31 @ Panhandle State 35 | |
| 10/30/2010 | Panhandle State 34 @ Southern Nazarene Crimson Storm 31 | |
| 11/6/2010 | Panhandle State 7 @ Northwestern Oklahoma State Rangers 31 | |
| 11/13/2010 | Bacone Warriors 20 @ Panhandle State 21 | |
| 11/20/2010 | Panhandle State 6 @ Lamar Cardinals 44 |