| 9/4/2010 | Western Michigan 14 @ Michigan State Spartans 38 | |
| 9/11/2010 | Nicholls State Colonels 14 @ Western Michigan 49 | |
| 9/18/2010 | Toledo Rockets 37 @ Western Michigan 24 | † |
| 10/2/2010 | Idaho Vandals 33 @ Western Michigan 13 | |
| 10/9/2010 | Western Michigan 45 @ Ball State Cardinals 16 | † |
| 10/16/2010 | Western Michigan 20 @ Notre Dame Fighting Irish 44 | |
| 10/23/2010 | Western Michigan 56 @ Akron Zips 10 | † |
| 10/30/2010 | Northern Illinois Huskies 28 @ Western Michigan 21 | † |
| 11/5/2010 | Western Michigan 22 @ Central Michigan Chippewas 26 | † |
| 11/13/2010 | Eastern Michigan Eagles 30 @ Western Michigan 45 | † |
| 11/20/2010 | Kent State Golden Flashes 3 @ Western Michigan 38 | † |
| 11/26/2010 | Western Michigan 41 @ Bowling Green Falcons 7 | † |