| 9/4/2010 | Sam Houston Bearkats 3 @ Baylor 34 | |
| 9/11/2010 | Buffalo Bulls 6 @ Baylor 34 | |
| 9/18/2010 | Baylor 10 @ TCU Horned Frogs 45 | |
| 9/25/2010 | Baylor 30 @ Rice Owls 13 | |
| 10/2/2010 | Kansas Jayhawks 7 @ Baylor 55 | † |
| 10/9/2010 | Texas Tech Red Raiders 45 vs Baylor 38 (Dallas TX) | † |
| 10/16/2010 | Baylor 31 @ Colorado Buffaloes 25 | † |
| 10/23/2010 | Kansas State Wildcats 42 @ Baylor 47 | † |
| 10/30/2010 | Baylor 30 @ Texas Longhorns 22 | † |
| 11/6/2010 | Baylor 28 @ Oklahoma State Cowboys 55 | † |
| 11/13/2010 | Texas A&M Aggies 42 @ Baylor 30 | † |
| 11/20/2010 | Oklahoma Sooners 53 @ Baylor 24 | † |
| 12/29/2010 | Illinois Fighting Illini 38 vs Baylor 14 (Houston - Texas Bowl) |