| 8/28/2010 | Bacone 20 @ Haskell Indians 16 | |
| 9/4/2010 | McMurry 41 @ Bacone 6 | |
| 9/11/2010 | Bacone 12 @ Southwest Baptist Bearcats 21 | |
| 9/25/2010 | Bacone 28 @ Nicholls State Colonels 44 | |
| 10/2/2010 | Bacone 13 @ Langston Lions 14 | † |
| 10/9/2010 | Southwestern Assemblies of God Lions 17 @ Bacone 66 | † |
| 10/16/2010 | Bacone 14 @ Northwestern Oklahoma State Rangers 51 | † |
| 10/23/2010 | Grand View Vikings 21 @ Bacone 18 | |
| 10/30/2010 | Texas College Steers 6 @ Bacone 54 | † |
| 11/6/2010 | Southern Nazarene Crimson Storm 41 @ Bacone 19 | † |
| 11/13/2010 | Bacone 20 @ Panhandle State Aggies 21 |