| 9/1/2022 | Central Michigan | 44 | at | Oklahoma State | 58 | MAC | ||
| West Virginia | 31 | at | Pittsburgh | 38 | @ ACC | |||
| 9/2/2022 | TCU | 38 | at | Colorado | 13 | @ P12 | ||
| Tennessee Tech | 10 | at | Kansas | 56 | OVC (1AA) | |||
| 9/3/2022 | Albany NY | 10 | at | Baylor | 69 | CAAF (1AA) | ||
| SE Missouri State | 10 | at | Iowa State | 42 | OVC (1AA) | |||
| South Dakota | 0 | at | Kansas State | 34 | MVC (1AA) | |||
| UTEP | 13 | at | Oklahoma | 45 | CUSA | |||
| UL Monroe | 10 | at | Texas | 52 | SBC | |||
| Murray State | 10 | at | Texas Tech | 63 | OVC (1AA) | |||
| 9/10/2022 | Baylor | 20 | at | BYU | 26 | @ Ind | ||
| Iowa State | 10 | at | Iowa | 7 | @ B10 | |||
| Missouri | 12 | at | Kansas State | 40 | SEC | |||
| Kent State | 3 | at | Oklahoma | 33 | MAC | |||
| Arizona State | 17 | at | Oklahoma State | 34 | P12 | |||
| Tarleton State | 17 | at | TCU | 59 | WAC (1AA) | |||
| Alabama | 20 | at | Texas | 19 | SEC | |||
| Houston | 30 | at | Texas Tech | 33 | 2OT | AAC | ||
| Kansas | 55 | at | West Virginia | 42 | OT | |||
| 9/17/2022 | Texas State | 7 | at | Baylor | 42 | SBC | ||
| Kansas | 48 | at | Houston | 30 | @ AAC | |||
| Ohio | 10 | at | Iowa State | 43 | MAC | |||
| Tulane | 17 | at | Kansas State | 10 | AAC | |||
| Oklahoma | 49 | at | Nebraska | 14 | @ B10 | |||
| Texas Tech | 14 | at | North Carolina State | 27 | @ ACC | |||
| Ark Pine Bluff | 7 | at | Oklahoma State | 63 | SWAC (1AA) | |||
| Texas-San Antonio | 20 | at | Texas | 41 | CUSA | |||
| Towson | 7 | at | West Virginia | 65 | CAAF (1AA) | |||
| 9/22/2022 | West Virginia | 33 | at | Virginia Tech | 10 | @ ACC | ||
| 9/24/2022 | Baylor | 31 | at | Iowa State | 24 | |||
| Duke | 27 | at | Kansas | 35 | ACC | |||
| Kansas State | 41 | at | Oklahoma | 34 | ||||
| TCU | 42 | at | SMU | 34 | @ AAC | |||
| Texas | 34 | at | Texas Tech | 37 | OT | |||
| 10/1/2022 | Oklahoma State | 36 | at | Baylor | 25 | |||
| Iowa State | 11 | at | Kansas | 14 | ||||
| Texas Tech | 28 | at | Kansas State | 37 | ||||
| Oklahoma | 24 | at | TCU | 55 | ||||
| West Virginia | 20 | at | Texas | 38 | ||||
| 10/8/2022 | Kansas State | 10 | at | Iowa State | 9 | |||
| TCU | 38 | at | Kansas | 31 | ||||
| Texas | 49 | vs | Oklahoma | 0 | Dallas TX | |||
| Texas Tech | 31 | at | Oklahoma State | 41 | ||||
| 10/13/2022 | Baylor | 40 | at | West Virginia | 43 | |||
| 10/15/2022 | Kansas | 42 | at | Oklahoma | 52 | |||
| Oklahoma State | 40 | at | TCU | 43 | 2OT | |||
| Iowa State | 21 | at | Texas | 24 | ||||
| 10/22/2022 | Kansas | 23 | at | Baylor | 35 | |||
| Texas | 34 | at | Oklahoma State | 41 | ||||
| Kansas State | 28 | at | TCU | 38 | ||||
| West Virginia | 10 | at | Texas Tech | 48 | ||||
| 10/29/2022 | Oklahoma | 27 | at | Iowa State | 13 | |||
| Oklahoma State | 0 | at | Kansas State | 48 | ||||
| Baylor | 45 | at | Texas Tech | 17 | ||||
| TCU | 41 | at | West Virginia | 31 | ||||
| 11/5/2022 | West Virginia | 14 | at | Iowa State | 31 | |||
| Oklahoma State | 16 | at | Kansas | 37 | ||||
| Texas | 34 | at | Kansas State | 27 | ||||
| Baylor | 38 | at | Oklahoma | 35 | ||||
| Texas Tech | 24 | at | TCU | 34 | ||||
| 11/12/2022 | Kansas State | 31 | at | Baylor | 3 | |||
| Iowa State | 14 | at | Oklahoma State | 20 | ||||
| TCU | 17 | at | Texas | 10 | ||||
| Kansas | 28 | at | Texas Tech | 43 | ||||
| Oklahoma | 20 | at | West Virginia | 23 | ||||
| 11/19/2022 | TCU | 29 | at | Baylor | 28 | |||
| Texas Tech | 14 | at | Iowa State | 10 | ||||
| Texas | 55 | at | Kansas | 14 | ||||
| Oklahoma State | 13 | at | Oklahoma | 28 | ||||
| Kansas State | 48 | at | West Virginia | 31 | ||||
| 11/25/2022 | Baylor | 27 | at | Texas | 38 | |||
| 11/26/2022 | Kansas | 27 | at | Kansas State | 47 | |||
| West Virginia | 24 | at | Oklahoma State | 19 | ||||
| Iowa State | 14 | at | TCU | 62 | ||||
| Oklahoma | 48 | at | Texas Tech | 51 | OT | |||
| 12/3/2022 | Kansas State | 31 | vs | TCU | 28 | OT | B12 Arlington TX | |
| 12/22/2022 | Baylor | 15 | vs | Air Force | 30 | Fort Worth TX | vs MW | |
| 12/27/2022 | Wisconsin | 24 | vs | Oklahoma State | 17 | Phoenix AZ | vs B10 | |
| 12/28/2022 | Kansas | 53 | vs | Arkansas | 55 | 3OT | Memphis TN | vs SEC |
| Texas Tech | 42 | vs | Mississippi | 25 | Houston TX | vs SEC | ||
| 12/29/2022 | Oklahoma | 32 | vs | Florida State | 35 | Orlando FL | vs ACC | |
| Texas | 20 | vs | Washington | 27 | San Antonio TX | vs P12 | ||
| 12/31/2022 | Alabama | 45 | vs | Kansas State | 20 | New Orleans LA | vs SEC | |
| TCU | 51 | vs | Michigan | 45 | Glendale AZ - FBS semifinal | vs B10 | ||
| 1/9/2023 | TCU | 7 | vs | Georgia | 65 | Inglewood CA - FBS Championship | vs SEC |