| 9/2/2022 | Virginia Tech | 17 | at | Old Dominion (3-9) | 20 | at SBC | ||
| 9/10/2022 | Boston College (3-9,2-6) | 10 | at | Virginia Tech | 27 | |||
| 9/17/2022 | Wofford (3-8) | 7 | at | Virginia Tech | 27 | SoCon (1AA) | ||
| 9/22/2022 | West Virginia (5-7) | 33 | at | Virginia Tech | 10 | B12 | ||
| 10/1/2022 | Virginia Tech | 10 | at | North Carolina (9-5,6-3) | 41 | |||
| 10/8/2022 | Virginia Tech | 29 | at | Pittsburgh (9-4,5-3) | 45 | |||
| 10/15/2022 | Miami-Florida (5-7,3-5) | 20 | at | Virginia Tech | 14 | |||
| 10/27/2022 | Virginia Tech | 21 | at | North Carolina State (8-5,4-4) | 22 | |||
| 11/5/2022 | Georgia Tech (5-7,4-4) | 28 | at | Virginia Tech | 27 | |||
| 11/12/2022 | Virginia Tech | 7 | at | Duke (9-4,5-3) | 24 | |||
| 11/19/2022 | Virginia Tech | 23 | at | Liberty (8-5) | 22 | at Ind | ||
| 11/25/2022 | Virginia (3-7,1-6) | at | Virginia Tech | Cancelled |
| vs Virginia Tech | vs Other Opponents | Virginia Tech compared to OOs | |
| Record: | 8-3 | 62-74 | |
| Points Scored: | 24.73 | 25.08 | 0.35 |
| Points Allowed: | 19.27 | 27.36 | -8.09 |
| Margin: | 5.46 | -2.28 | -7.74 |
| Total Points: | 44.00 | 52.44 | -8.44 |