| 9/3/2022 | South Dakota | 0 | at | Kansas State (10-4) | 34 | at B12 | ||
| 9/10/2022 | South Dakota | 7 | at | Montana (8-5) | 24 | at BSky | ||
| 9/17/2022 | Cal Poly (2-9) | 21 | at | South Dakota | 38 | BSky | ||
| 9/24/2022 | North Dakota State (12-3,7-2) | 34 | at | South Dakota | 17 | |||
| 10/8/2022 | South Dakota | 3 | at | South Dakota State (14-1,9-0) | 28 | |||
| 10/15/2022 | South Dakota | 10 | at | Illinois State (6-5,4-4) | 12 | |||
| 10/22/2022 | Southern Illinois (5-6,4-4) | 24 | at | South Dakota | 27 | |||
| 10/29/2022 | South Dakota | 24 | at | Youngstown State (7-4,5-3) | 45 | |||
| 11/5/2022 | Missouri State (5-6,3-5) | 13 | at | South Dakota | 20 | |||
| 11/12/2022 | South Dakota | 19 | at | North Dakota (7-5,5-3) | 28 | |||
| 11/19/2022 | Northern Iowa (6-5,5-3) | 58 | at | South Dakota | 14 |
| vs South Dakota | vs Other Opponents | South Dakota compared to OOs | |
| Record: | 8-3 | 74-50 | |
| Points Scored: | 29.18 | 29.94 | 0.76 |
| Points Allowed: | 16.27 | 25.49 | -9.22 |
| Margin: | 12.91 | 4.45 | -8.46 |
| Total Points: | 45.45 | 55.43 | -9.98 |