| 9/1/2022 | West Virginia (5-7) | 31 | at | Pittsburgh | 38 | B12 | ||
| 9/10/2022 | Tennessee (11-2) | 34 | at | Pittsburgh | 27 | OT | SEC | |
| 9/17/2022 | Pittsburgh | 34 | at | Western Michigan (5-7) | 13 | at MAC | ||
| 9/24/2022 | Rhode Island (7-4) | 24 | at | Pittsburgh | 45 | CAAF (1AA) | ||
| 10/1/2022 | Georgia Tech (5-7,4-4) | 26 | at | Pittsburgh | 21 | |||
| 10/8/2022 | Virginia Tech (3-8,1-6) | 29 | at | Pittsburgh | 45 | |||
| 10/22/2022 | Pittsburgh | 10 | at | Louisville (8-5,4-4) | 24 | |||
| 10/29/2022 | Pittsburgh | 24 | at | North Carolina (9-5,6-3) | 42 | |||
| 11/5/2022 | Syracuse (7-6,4-4) | 9 | at | Pittsburgh | 19 | |||
| 11/12/2022 | Pittsburgh | 37 | at | Virginia (3-7,1-6) | 7 | |||
| 11/19/2022 | Duke (9-4,5-3) | 26 | at | Pittsburgh | 28 | |||
| 11/26/2022 | Pittsburgh | 42 | at | Miami-Florida (5-7,3-5) | 16 | |||
| 12/30/2022 | Pittsburgh | 37 | vs | UCLA (9-4) | 35 | El Paso TX | vs P12 |
| vs Pittsburgh | vs Other Opponents | Pittsburgh compared to OOs | |
| Record: | 4-9 | 82-64 | |
| Points Scored: | 24.31 | 28.87 | 4.56 |
| Points Allowed: | 31.31 | 25.23 | 6.08 |
| Margin: | -7.00 | 3.64 | 10.64 |
| Total Points: | 55.62 | 54.10 | 1.52 |