| 9/3/2022 | Massachusetts (1-11) | 10 | at | Tulane | 42 | Ind | ||
| 9/10/2022 | Alcorn State (5-6) | 0 | at | Tulane | 52 | SWAC (1AA) | ||
| 9/17/2022 | Tulane | 17 | at | Kansas State (10-4) | 10 | at B12 | ||
| 9/24/2022 | Southern Miss (7-6) | 27 | at | Tulane | 24 | SBC | ||
| 9/30/2022 | Tulane | 27 | at | Houston (8-5,5-3) | 24 | OT | ||
| 10/8/2022 | East Carolina (8-5,4-4) | 9 | at | Tulane | 24 | |||
| 10/15/2022 | Tulane | 45 | at | South Florida (1-11,0-8) | 31 | |||
| 10/22/2022 | Memphis (7-6,3-5) | 28 | at | Tulane | 38 | |||
| 11/5/2022 | Tulane | 27 | at | Tulsa (5-7,3-5) | 13 | |||
| 11/12/2022 | UCF (9-5,6-3) | 38 | at | Tulane | 31 | |||
| 11/17/2022 | SMU (7-6,5-3) | 24 | at | Tulane | 59 | |||
| 11/25/2022 | Tulane | 27 | at | Cincinnati (9-4,6-2) | 24 | |||
| 12/3/2022 | UCF (9-5,6-3) | 28 | at | Tulane | 45 | AAC Championship | ||
| 1/2/2023 | Tulane | 46 | vs | Southern California (11-3) | 45 | Arlington TX | vs P12 |
| vs Tulane | vs Other Opponents | Tulane compared to OOs | |
| Record: | 2-12 | 94-71 | |
| Points Scored: | 22.21 | 31.91 | 9.70 |
| Points Allowed: | 36.00 | 27.48 | 8.52 |
| Margin: | -13.79 | 4.43 | 18.22 |
| Total Points: | 58.21 | 59.39 | -1.18 |