| 9/3/2022 | South Dakota State (14-1) | 3 | at | Iowa | 7 | MVC (1AA) | ||
| 9/10/2022 | Iowa State (4-8) | 10 | at | Iowa | 7 | B12 | ||
| 9/17/2022 | Nevada (2-10) | 0 | at | Iowa | 27 | MW | ||
| 9/24/2022 | Iowa | 27 | at | Rutgers (4-8,1-8) | 10 | |||
| 10/1/2022 | Michigan (13-1,10-0) | 27 | at | Iowa | 14 | |||
| 10/8/2022 | Iowa | 6 | at | Illinois (8-5,5-4) | 9 | |||
| 10/22/2022 | Iowa | 10 | at | Ohio State (11-2,8-1) | 54 | |||
| 10/29/2022 | Northwestern (1-11,1-8) | 13 | at | Iowa | 33 | |||
| 11/5/2022 | Iowa | 24 | at | Purdue (8-6,6-4) | 3 | |||
| 11/12/2022 | Wisconsin (7-6,4-5) | 10 | at | Iowa | 24 | |||
| 11/19/2022 | Iowa | 13 | at | Minnesota (9-4,5-4) | 10 | |||
| 11/25/2022 | Nebraska (4-8,3-6) | 24 | at | Iowa | 17 | |||
| 12/31/2022 | Iowa | 21 | vs | Kentucky (7-6) | 0 | Nashville TN | vs SEC |
| vs Iowa | vs Other Opponents | Iowa compared to OOs | |
| Record: | 5-8 | 87-68 | |
| Points Scored: | 13.31 | 27.45 | 14.14 |
| Points Allowed: | 17.69 | 21.83 | -4.14 |
| Margin: | -4.38 | 5.62 | 10.00 |
| Total Points: | 31.00 | 49.28 | -18.28 |