| 8/27/2022 | Duquesne (4-7) | 7 | at | Florida State | 47 | NE (1AA) | ||
| 9/4/2022 | Florida State | 24 | vs | LSU (10-4) | 23 | New Orleans LA | vs SEC | |
| 9/16/2022 | Florida State | 35 | at | Louisville (8-5,4-4) | 31 | |||
| 9/24/2022 | Boston College (3-9,2-6) | 14 | at | Florida State | 44 | |||
| 10/1/2022 | Wake Forest (8-5,3-5) | 31 | at | Florida State | 21 | |||
| 10/8/2022 | Florida State | 17 | at | North Carolina State (8-5,4-4) | 19 | |||
| 10/15/2022 | Clemson (11-3,9-0) | 34 | at | Florida State | 28 | |||
| 10/29/2022 | Georgia Tech (5-7,4-4) | 16 | at | Florida State | 41 | |||
| 11/5/2022 | Florida State | 45 | at | Miami-Florida (5-7,3-5) | 3 | |||
| 11/12/2022 | Florida State | 38 | at | Syracuse (7-6,4-4) | 3 | |||
| 11/19/2022 | UL Lafayette (6-7) | 17 | at | Florida State | 49 | SBC | ||
| 11/25/2022 | Florida (6-7) | 38 | at | Florida State | 45 | SEC | ||
| 12/29/2022 | Oklahoma (6-7) | 32 | vs | Florida State | 35 | Orlando FL | B12 |
| vs Florida State | vs Other Opponents | Florida State compared to OOs | |
| Record: | 3-10 | 84-69 | |
| Points Scored: | 20.62 | 28.09 | 7.47 |
| Points Allowed: | 36.08 | 24.15 | 11.93 |
| Margin: | -15.46 | 3.94 | 19.40 |
| Total Points: | 56.70 | 52.24 | 4.46 |