| 9/1/2022 | The Citadel | 10 | at | Campbell | 29 | SoCon | ||
| Bryant | 37 | at | Florida Intl | 38 | OT | @ CUSA (1A) | ||
| Limestone | 21 | at | Gardner-Webb | 56 | SAC (D2) | |||
| 9/3/2022 | Western Carolina | 52 | at | Charleston Southern | 38 | SoCon | ||
| North Carolina A&T | 13 | vs | North Carolina Central | 28 | Charlotte NC | vs MEAC | ||
| Dayton | 22 | at | Robert Morris | 20 | Pio | |||
| 9/10/2022 | Rhode Island | 35 | at | Bryant | 21 | CAAF | ||
| Gardner-Webb | 27 | at | Coastal Carolina | 31 | @ SBC (1A) | |||
| Robert Morris | 14 | at | Miami-Ohio | 31 | @ MAC (1A) | |||
| Charleston Southern | 3 | at | North Carolina State | 55 | @ ACC (1A) | |||
| North Carolina A&T | 3 | at | North Dakota State | 43 | @ MVC | |||
| Campbell | 21 | at | William & Mary | 37 | @ CAAF | |||
| 9/17/2022 | Bryant | 38 | at | Brown | 44 | 2OT | @ Ivy | |
| North Carolina A&T | 20 | at | Duke | 49 | @ ACC (1A) | |||
| Campbell | 10 | at | East Carolina | 49 | @ AAC (1A) | |||
| Charleston Southern | 17 | at | Eastern Kentucky | 40 | @ ASUN | |||
| Gardner-Webb | 24 | at | Elon | 30 | @ CAAF | |||
| 9/24/2022 | Furman | 24 | at | Charleston Southern | 19 | SoCon | ||
| Mercer | 45 | at | Gardner-Webb | 14 | SoCon | |||
| Bryant | 31 | at | LIU | 29 | @ NE | |||
| South Carolina State | 27 | at | North Carolina A&T | 41 | MEAC | |||
| East Tennessee St | 45 | at | Robert Morris | 3 | SoCon | |||
| 10/1/2022 | North Carolina Central | 18 | at | Campbell | 48 | MEAC | ||
| Robert Morris | 9 | at | Delaware State | 14 | @ MEAC | |||
| Gardner-Webb | 7 | at | Marshall | 28 | @ SBC (1A) | |||
| Bryant | 13 | at | North Carolina A&T | 24 | ||||
| 10/8/2022 | Southern Connecticut | 10 | at | Bryant | 56 | NE10 (D2) | ||
| Charleston Southern | 28 | at | Campbell | 34 | ||||
| Gardner-Webb | 48 | at | Robert Morris | 0 | ||||
| 10/15/2022 | Charleston Southern | 24 | at | Bryant | 23 | |||
| Robert Morris | 10 | at | Campbell | 41 | ||||
| Gardner-Webb | 20 | at | Liberty | 21 | @ Ind (1A) | |||
| Edward Waters | 7 | at | North Carolina A&T | 45 | SIAC (D2) | |||
| 10/22/2022 | Gardner-Webb | 28 | at | Charleston Southern | 14 | |||
| Campbell | 14 | at | Jackson State | 22 | @ SWAC | |||
| North Carolina A&T | 38 | at | Robert Morris | 14 | ||||
| 10/29/2022 | Robert Morris | 3 | at | Appalachian State | 42 | @ SBC (1A) | ||
| Bryant | 40 | at | Gardner-Webb | 48 | ||||
| Charleston Southern | 20 | at | Kennesaw St | 30 | @ ASUN | |||
| Campbell | 38 | at | North Carolina A&T | 45 | ||||
| 11/5/2022 | Campbell | 37 | at | Bryant | 43 | |||
| Robert Morris | 21 | at | Charleston Southern | 34 | ||||
| Norfolk State | 24 | at | North Carolina A&T | 49 | MEAC | |||
| 11/12/2022 | Gardner-Webb | 42 | at | Campbell | 35 | |||
| Bryant | 29 | at | Holy Cross | 36 | @ Pat | |||
| Robert Morris | 9 | at | Murray State | 27 | @ OVC | |||
| Charleston Southern | 10 | at | North Carolina A&T | 20 | ||||
| 11/19/2022 | Campbell | 34 | at | Delaware State | 7 | @ MEAC | ||
| North Carolina A&T | 17 | at | Gardner-Webb | 38 | ||||
| Bryant | 35 | at | Robert Morris | 6 | ||||
| 11/26/2022 | Gardner-Webb | 52 | at | Eastern Kentucky | 41 | FCS Championship - Round 1 | @ ASUN | |
| 12/3/2022 | Gardner-Webb | 14 | at | William & Mary | 54 | FCS Playoffs Round 2 | @ CAAF |