| 9/1/2022 | Bryant (4-7) | 37 | at | Florida Intl | 38 | OT | BigS (1AA) | |
| 9/10/2022 | Florida Intl | 12 | at | Texas State (4-8) | 41 | at SBC | ||
| 9/24/2022 | Florida Intl | 0 | at | Western Kentucky (9-5,6-2) | 73 | |||
| 10/1/2022 | Florida Intl | 21 | at | New Mexico State (7-6) | 7 | at Ind | ||
| 10/8/2022 | Connecticut (6-7) | 33 | at | Florida Intl | 12 | Ind | ||
| 10/14/2022 | Texas-San Antonio (11-3,9-0) | 30 | at | Florida Intl | 10 | |||
| 10/22/2022 | Florida Intl | 34 | at | UNC-Charlotte (3-9,2-6) | 15 | |||
| 10/28/2022 | Louisiana Tech (3-9,2-6) | 34 | at | Florida Intl | 42 | 2OT | ||
| 11/5/2022 | Florida Intl | 14 | at | North Texas (7-7,6-3) | 52 | |||
| 11/12/2022 | Florida Atlantic (5-7,4-4) | 52 | at | Florida Intl | 7 | |||
| 11/19/2022 | Florida Intl | 6 | at | UTEP (5-7,3-5) | 40 | |||
| 11/26/2022 | Middle Tenn State (8-5,4-4) | 33 | at | Florida Intl | 28 |
| vs Florida Intl | vs Other Opponents | Florida Intl compared to OOs | |
| Record: | 8-4 | 64-76 | |
| Points Scored: | 37.25 | 27.99 | -9.26 |
| Points Allowed: | 18.67 | 29.58 | -10.91 |
| Margin: | 18.58 | -1.59 | -20.17 |
| Total Points: | 55.92 | 57.57 | -1.65 |