| 8/27/2022 | Morehead State (2-9) | 13 | at | Mercer | 63 | Pio | ||
| 9/3/2022 | Mercer | 16 | at | Auburn (5-7) | 42 | at SEC | ||
| 9/17/2022 | The Citadel (4-7,3-5) | 0 | at | Mercer | 17 | |||
| 9/24/2022 | Mercer | 45 | at | Gardner-Webb (7-6) | 14 | at BigS | ||
| 10/1/2022 | Mercer | 42 | at | Wofford (3-8,3-5) | 7 | |||
| 10/8/2022 | Western Carolina (6-5,4-4) | 6 | at | Mercer | 49 | |||
| 10/15/2022 | East Tennessee St (3-8,1-7) | 33 | at | Mercer | 55 | |||
| 10/22/2022 | Mercer | 21 | at | Chattanooga (7-4,5-3) | 41 | |||
| 10/29/2022 | Mercer | 55 | at | VMI (1-10,0-8) | 14 | |||
| 11/12/2022 | Furman (10-3,7-1) | 23 | at | Mercer | 13 | |||
| 11/19/2022 | Mercer | 44 | at | Samford (11-2,8-0) | 50 | 2OT |
| vs Mercer | vs Other Opponents | Mercer compared to OOs | |
| Record: | 4-7 | 55-62 | |
| Points Scored: | 22.09 | 27.16 | 5.07 |
| Points Allowed: | 38.18 | 27.78 | 10.40 |
| Margin: | -16.09 | -0.62 | 15.47 |
| Total Points: | 60.27 | 54.94 | 5.33 |