| 9/3/2022 | Norfolk State (2-9) | 3 | at | Marshall | 55 | MEAC (1AA) | ||
| 9/10/2022 | Marshall | 26 | at | Notre Dame (9-4) | 21 | at ND | ||
| 9/17/2022 | Marshall | 31 | at | Bowling Green (6-7) | 34 | OT | at MAC | |
| 9/24/2022 | Marshall | 7 | at | Troy (12-2,8-1) | 16 | |||
| 10/1/2022 | Gardner-Webb (7-6) | 7 | at | Marshall | 28 | BigS (1AA) | ||
| 10/12/2022 | UL Lafayette (6-7,4-4) | 23 | at | Marshall | 13 | |||
| 10/22/2022 | Marshall | 26 | at | James Madison (8-3,6-2) | 12 | |||
| 10/29/2022 | Coastal Carolina (9-4,6-3) | 24 | at | Marshall | 13 | |||
| 11/5/2022 | Marshall | 12 | at | Old Dominion (3-9,2-6) | 0 | |||
| 11/12/2022 | Appalachian State (6-6,3-5) | 21 | at | Marshall | 28 | |||
| 11/19/2022 | Marshall | 23 | at | Georgia Southern (6-7,3-5) | 10 | |||
| 11/26/2022 | Georgia State (4-8,3-5) | 23 | at | Marshall | 28 | |||
| 12/19/2022 | Marshall | 28 | vs | Connecticut (6-7) | 14 | Conway SC | vs Ind |
| vs Marshall | vs Other Opponents | Marshall compared to OOs | |
| Record: | 4-9 | 80-70 | |
| Points Scored: | 16.00 | 28.60 | 12.60 |
| Points Allowed: | 24.46 | 27.81 | -3.35 |
| Margin: | -8.46 | 0.79 | 9.25 |
| Total Points: | 40.46 | 56.41 | -15.95 |