| 9/2/2022 | Holy Cross | 31 | at | Merrimack (8-3) | 17 | at NE | ||
| 9/10/2022 | Holy Cross | 37 | at | Buffalo (7-6) | 31 | at MAC | ||
| 9/17/2022 | Yale (8-2) | 14 | at | Holy Cross | 38 | Ivy | ||
| 9/24/2022 | Holy Cross | 35 | at | Colgate (3-8,2-4) | 10 | |||
| 10/1/2022 | Holy Cross | 30 | at | Harvard (6-4) | 21 | at Ivy | ||
| 10/8/2022 | Bucknell (3-8,2-4) | 0 | at | Holy Cross | 57 | |||
| 10/22/2022 | Holy Cross | 24 | at | Lafayette (4-7,3-3) | 21 | |||
| 10/29/2022 | Fordham (9-3,5-1) | 52 | at | Holy Cross | 53 | OT | ||
| 11/5/2022 | Lehigh (2-9,2-4) | 14 | at | Holy Cross | 42 | |||
| 11/12/2022 | Bryant (4-7) | 29 | at | Holy Cross | 36 | BigS | ||
| 11/19/2022 | Holy Cross | 47 | at | Georgetown (2-9,1-5) | 10 | |||
| 12/3/2022 | New Hampshire (9-4) | 19 | at | Holy Cross | 35 | FCS Playoffs Round 2 | CAAF | |
| 12/10/2022 | Holy Cross | 21 | at | South Dakota State (14-1) | 42 | FCS Quarterful | at MVC |
| vs Holy Cross | vs Other Opponents | Holy Cross compared to OOs | |
| Record: | 1-12 | 78-59 | |
| Points Scored: | 21.54 | 27.63 | 6.09 |
| Points Allowed: | 37.38 | 25.74 | 11.64 |
| Margin: | -15.84 | 1.89 | 17.73 |
| Total Points: | 58.92 | 53.37 | 5.55 |