| 9/3/2022 | Elon | 31 | at | Vanderbilt (5-7) | 42 | at SEC | ||
| 9/10/2022 | Elon | 26 | at | Wofford (3-8) | 0 | at SoCon | ||
| 9/17/2022 | Gardner-Webb (7-6) | 24 | at | Elon | 30 | BigS | ||
| 9/24/2022 | Elon | 35 | at | William & Mary (11-2,7-1) | 31 | |||
| 10/1/2022 | Richmond (9-4,6-2) | 27 | at | Elon | 30 | 2OT | ||
| 10/8/2022 | Towson (6-5,4-4) | 10 | at | Elon | 27 | |||
| 10/15/2022 | Elon | 10 | at | Rhode Island (7-4,5-3) | 17 | |||
| 10/22/2022 | Elon | 22 | at | New Hampshire (9-4,7-1) | 40 | |||
| 10/29/2022 | Delaware (8-5,4-4) | 7 | at | Elon | 27 | |||
| 11/5/2022 | Albany NY (3-8,2-6) | 3 | at | Elon | 27 | |||
| 11/12/2022 | Elon | 38 | at | Hampton (4-7,1-7) | 24 | |||
| 11/26/2022 | Elon | 6 | at | Furman (10-3) | 31 | FCS Championship - Round 1 | at SoCon |
| vs Elon | vs Other Opponents | Elon compared to OOs | |
| Record: | 4-8 | 78-55 | |
| Points Scored: | 21.33 | 28.71 | 7.38 |
| Points Allowed: | 25.75 | 26.65 | -0.90 |
| Margin: | -4.42 | 2.06 | 6.48 |
| Total Points: | 47.08 | 55.36 | -8.28 |