| 9/1/2022 | Limestone | 21 | at | Gardner-Webb (7-6) | 56 | at BigS | ||
| 9/10/2022 | Limestone | 73 | at | St Augustine's (1-9) | 14 | at CIAA | ||
| 9/17/2022 | Limestone | 40 | at | Carson-Newman (6-5,5-4) | 37 | 2OT | ||
| 9/24/2022 | Virginia-Wise (2-9,1-8) | 13 | at | Limestone | 27 | |||
| 9/29/2022 | Limestone | 17 | at | Mars Hill (7-3,7-2) | 14 | |||
| 10/8/2022 | Limestone | 30 | at | Lenoir-Rhyne (8-3,7-2) | 51 | |||
| 10/15/2022 | Wingate (11-3,7-2) | 28 | at | Limestone | 21 | |||
| 10/22/2022 | Limestone | 48 | at | Catawba (1-10,0-9) | 23 | |||
| 10/29/2022 | Limestone | 42 | at | Newberry (9-2,7-2) | 37 | |||
| 11/5/2022 | Barton (4-7,3-6) | 28 | at | Limestone | 34 | |||
| 11/12/2022 | Emory & Henry (5-6,4-5) | 27 | at | Limestone | 45 | |||
| 11/19/2022 | Limestone | 19 | at | West Florida (12-2) | 45 | D2 Championship Round 1 | at GSC |
| vs Limestone | vs Other Opponents | Limestone compared to OOs | |
| Record: | 4-8 | 69-57 | |
| Points Scored: | 31.08 | 26.40 | -4.68 |
| Points Allowed: | 34.75 | 25.14 | 9.61 |
| Margin: | -3.67 | 1.26 | 4.93 |
| Total Points: | 65.83 | 51.54 | 14.29 |