| 9/1/2022 | South Dakota Tech | 43 | at | Missouri S&T | 20 | RMAC | ||
| McKendree | 31 | at | Northern Michigan | 24 | OT | @ GLIAC | ||
| Glenville State | 44 | at | Quincy | 15 | MtnE | |||
| Colorado Mesa | 37 | at | William Jewell | 14 | RMAC | |||
| 9/3/2022 | St Xavier | 0 | at | Indianapolis | 57 | MSFA (NAIA) | ||
| Southwest Baptist | 41 | at | Texas-Permian Basin | 17 | @ LSC | |||
| Davenport | 20 | at | Truman State | 19 | GLIAC | |||
| 9/8/2022 | Trinity International | 14 | at | Quincy | 53 | MSFA (NAIA) | ||
| 9/10/2022 | William Jewell | 19 | at | Black Hills State | 38 | @ RMAC | ||
| Missouri S&T | 17 | at | Drake | 14 | OT | @ Pio (1AA) | ||
| Delta State | 58 | at | McKendree | 34 | GSC | |||
| Truman State | 27 | at | South Dakota Tech | 20 | @ RMAC | |||
| West Florida | 49 | at | Southwest Baptist | 10 | GSC | |||
| 9/17/2022 | Southwest Baptist | 35 | at | Findlay | 52 | @ GMAC | ||
| Truman State | 21 | at | Hillsdale | 13 | @ GMAC | |||
| Missouri S&T | 6 | at | Kentucky Wesleyan | 11 | @ GMAC | |||
| McKendree | 38 | at | Lake Erie | 37 | @ GMAC | |||
| William Jewell | 21 | at | Ohio Dominican | 31 | @ GMAC | |||
| Indianapolis | 27 | at | Tiffin | 20 | @ GMAC | |||
| Quincy | 28 | at | Walsh | 13 | @ GMAC | |||
| 9/24/2022 | Walsh | 10 | at | McKendree | 46 | GMAC | ||
| Hillsdale | 17 | at | Missouri S&T | 10 | GMAC | |||
| Indianapolis | 44 | at | Ohio Dominican | 38 | @ GMAC | |||
| Ashland | 34 | at | Quincy | 14 | GMAC | |||
| Lake Erie | 31 | at | Southwest Baptist | 52 | GMAC | |||
| Tiffin | 17 | at | Truman State | 18 | OT | GMAC | ||
| Kentucky Wesleyan | 17 | at | William Jewell | 24 | GMAC | |||
| 10/1/2022 | Southwest Baptist | 17 | at | Indianapolis | 44 | |||
| Quincy | 24 | at | Missouri S&T | 31 | ||||
| McKendree | 45 | at | William Jewell | 34 | ||||
| 10/8/2022 | Indianapolis | 38 | at | McKendree | 23 | |||
| Kentucky Wesleyan | 9 | at | Quincy | 46 | GMAC | |||
| William Jewell | 21 | at | Southwest Baptist | 44 | ||||
| Missouri S&T | 14 | at | Truman State | 36 | ||||
| 10/15/2022 | Quincy | 63 | at | McKendree | 62 | OT | ||
| Indianapolis | 14 | at | Saginaw Valley State | 38 | @ GLIAC | |||
| Southwest Baptist | 20 | at | Truman State | 25 | ||||
| Missouri S&T | 41 | at | William Jewell | 14 | ||||
| 10/22/2022 | Quincy | 38 | at | Indianapolis | 52 | |||
| McKendree | 42 | at | Missouri S&T | 35 | ||||
| Southwest Baptist | 10 | at | Tarleton State | 24 | @ WAC (1AA) | |||
| Truman State | 42 | at | William Jewell | 7 | ||||
| 10/29/2022 | Missouri S&T | 16 | at | Indianapolis | 42 | |||
| William Jewell | 23 | at | Lindenwood | 64 | @ OVC (1AA) | |||
| Southwest Baptist | 49 | at | McKendree | 31 | ||||
| Truman State | 59 | at | Quincy | 32 | ||||
| 11/5/2022 | Quincy | 24 | at | Southwest Baptist | 42 | |||
| McKendree | 7 | at | Truman State | 52 | ||||
| Indianapolis | 48 | at | William Jewell | 14 | ||||
| 11/12/2022 | Truman State | 14 | at | Indianapolis | 28 | |||
| McKendree | 35 | at | Lindenwood | 63 | @ OVC (1AA) | |||
| Southwest Baptist | 24 | at | Missouri S&T | 17 | ||||
| William Jewell | 17 | at | Quincy | 7 | ||||
| 11/19/2022 | Indianapolis | 0 | at | Pittsburg State | 35 | D2 Championship Round 1 | @ MAIAA | |
| 12/3/2022 | Tiffin | 27 | vs | Truman State | 28 | Hobart IN | vs GMAC |