| 9/1/2022 | Glenville State | 44 | at | Quincy (4-7) | 15 | | | at GLV |
| 9/10/2022 | Glenville State | 7 | at | Concord (9-2,8-2) | 21 | | | |
| 9/17/2022 | UNC Pembroke (5-6,5-5) | 17 | at | Glenville State | 45 | | | |
| 9/24/2022 | Glenville State | 23 | at | Wheeling (7-4,6-4) | 34 | | | |
| 10/1/2022 | West Liberty (4-7,3-7) | 14 | at | Glenville State | 35 | | | |
| 10/8/2022 | Glenville State | 34 | at | Charleston WV (6-5,6-4) | 41 | | | |
| 10/15/2022 | Alderson-Broaddus (0-11,0-10) | 12 | at | Glenville State | 31 | | | |
| 10/22/2022 | Glenville State | 16 | at | Notre Dame OH (9-3,9-1) | 38 | | | |
| 10/29/2022 | West Virginia State (7-4,6-4) | 30 | at | Glenville State | 31 | | | |
| 11/5/2022 | Glenville State | 38 | at | Fairmont State (3-8,3-7) | 36 | | | |
| 11/12/2022 | West Virginia Wesleyan (1-10,1-9) | 14 | at | Glenville State | 27 | | | |