| 9/3/2022 | St Xavier | 0 | at | Indianapolis (9-2) | 57 | | | at GLV |
| 9/10/2022 | St Thomas FL (8-2) | 31 | at | St Xavier | 10 | | | Sun |
| 9/17/2022 | Siena Heights (5-5,5-5) | 21 | at | St Xavier | 24 | | | |
| 9/24/2022 | St Xavier | 25 | at | St Francis IN (4-6,4-6) | 20 | | | |
| 10/1/2022 | Roosevelt (7-3,6-3) | 20 | at | St Xavier | 21 | | | |
| 10/8/2022 | St Xavier | 17 | at | Olivet Nazarene (7-4,6-4) | 10 | | | |
| 10/15/2022 | Missouri Baptist (4-7,3-6) | 13 | at | St Xavier | 31 | | | |
| 10/22/2022 | St Xavier | 35 | at | Trinity International (1-10,1-8) | 6 | | | |
| 10/29/2022 | St Xavier | 52 | at | Judson (2-8,2-8) | 6 | | | |
| 11/5/2022 | Saint Ambrose (2-8,2-7) | 14 | at | St Xavier | 31 | | | |
| 11/12/2022 | St Francis IL (7-3,7-3) | 21 | at | St Xavier | 24 | | | |
| 11/19/2022 | St Xavier | 7 | at | Marian IN (9-2,9-1) | 41 | | NAIA Championship Round 1 | |