| 9/3/2022 | Delta State | 33 | at | Kentucky State (4-6) | 10 | at SIAC | ||
| 9/10/2022 | Delta State | 58 | at | McKendree (5-6) | 34 | at GLV | ||
| 9/17/2022 | Delta State | 28 | at | Mississippi Valley State (2-9) | 17 | at SWAC | ||
| 9/24/2022 | Delta State | 45 | at | West Florida (12-2,8-1) | 42 | 2OT | ||
| 10/1/2022 | Valdosta State (5-6,3-5) | 31 | at | Delta State | 70 | |||
| 10/8/2022 | Delta State | 47 | at | North Greenville (3-8,2-6) | 14 | |||
| 10/15/2022 | West Alabama (5-6,3-5) | 7 | at | Delta State | 20 | |||
| 10/20/2022 | Delta State | 45 | at | Shorter (3-8,1-7) | 10 | |||
| 10/29/2022 | Delta State | 52 | at | Mississippi College (4-7,3-5) | 38 | |||
| 11/5/2022 | West Georgia (8-2,6-2) | 52 | at | Delta State | 42 | |||
| 11/12/2022 | West Alabama (5-6,3-5) | 7 | at | Delta State | 17 | |||
| 11/19/2022 | Fayetteville State (9-3) | 0 | at | Delta State | 51 | D2 Championship Round 1 | CIAA | |
| 11/26/2022 | West Florida (12-2,8-1) | 38 | at | Delta State | 27 | D2 Playoffs Round 2 |
| vs Delta State | vs Other Opponents | Delta State compared to OOs | |
| Record: | 2-11 | 74-57 | |
| Points Scored: | 23.08 | 31.05 | 7.97 |
| Points Allowed: | 41.15 | 27.85 | 13.30 |
| Margin: | -18.07 | 3.20 | 21.27 |
| Total Points: | 64.23 | 58.90 | 5.33 |