| 9/1/2022 | McKendree (5-6) | 31 | at | Northern Michigan | 24 | OT | GLV | |
| 9/10/2022 | Wisconsin-Oshkosh (6-4) | 10 | at | Northern Michigan | 13 | WIAC (D3) | ||
| 9/17/2022 | Northern Michigan | 21 | at | Davenport (8-3,5-3) | 31 | |||
| 9/24/2022 | Post (0-10) | 14 | at | Northern Michigan | 42 | D2Ind | ||
| 10/1/2022 | Northern Michigan | 37 | at | Wayne State MI (1-9,0-7) | 30 | |||
| 10/8/2022 | Davenport (8-3,5-3) | 27 | at | Northern Michigan | 24 | OT | ||
| 10/15/2022 | Northern Michigan | 7 | at | Michigan Tech (4-7,2-5) | 21 | |||
| 10/22/2022 | Northern Michigan | 3 | at | Grand Valley State (12-1,7-1) | 56 | |||
| 10/29/2022 | Ferris State (14-1,7-1) | 56 | at | Northern Michigan | 20 | |||
| 11/5/2022 | Saginaw Valley State (8-3,4-3) | 30 | at | Northern Michigan | 21 | |||
| 11/12/2022 | Northern Michigan | 33 | at | Lake Erie (3-8) | 11 | at GMAC |
| vs Northern Michigan | vs Other Opponents | Northern Michigan compared to OOs | |
| Record: | 7-4 | 60-51 | |
| Points Scored: | 28.82 | 30.16 | 1.34 |
| Points Allowed: | 22.27 | 28.26 | -5.99 |
| Margin: | 6.55 | 1.90 | -4.65 |
| Total Points: | 51.09 | 58.42 | -7.33 |