| 9/1/2022 | West Virginia Wesleyan (1-10) | 0 | at | Saginaw Valley State | 72 | MtnE | ||
| 9/10/2022 | Bowie State (6-4) | 12 | at | Saginaw Valley State | 40 | CIAA | ||
| 9/17/2022 | Saginaw Valley State | 35 | at | Northwood (3-8) | 14 | at GMAC | ||
| 9/24/2022 | Saginaw Valley State | 35 | at | Michigan Tech (4-7,2-5) | 13 | |||
| 10/1/2022 | Saginaw Valley State | 10 | at | Grand Valley State (12-1,7-1) | 29 | |||
| 10/8/2022 | Ferris State (14-1,7-1) | 33 | at | Saginaw Valley State | 28 | |||
| 10/15/2022 | Indianapolis (9-2) | 14 | at | Saginaw Valley State | 38 | GLV | ||
| 10/22/2022 | Saginaw Valley State | 21 | at | Wayne State MI (1-9,0-7) | 14 | |||
| 10/29/2022 | Davenport (8-3,5-3) | 29 | at | Saginaw Valley State | 28 | |||
| 11/5/2022 | Saginaw Valley State | 30 | at | Northern Michigan (4-7,1-6) | 21 | |||
| 11/12/2022 | Michigan Tech (4-7,2-5) | 30 | at | Saginaw Valley State | 35 |
| vs Saginaw Valley State | vs Other Opponents | Saginaw Valley State compared to OOs | |
| Record: | 3-8 | 63-49 | |
| Points Scored: | 19.00 | 28.51 | 9.51 |
| Points Allowed: | 33.82 | 26.02 | 7.80 |
| Margin: | -14.82 | 2.49 | 17.31 |
| Total Points: | 52.82 | 54.53 | -1.71 |