| 9/3/2022 | Findlay (7-4,6-2) | 14 | at | Ohio Dominican | 28 | |||
| 9/10/2022 | Ohio Dominican | 13 | at | Tiffin (6-5,6-2) | 28 | |||
| 9/17/2022 | William Jewell (2-9) | 21 | at | Ohio Dominican | 31 | GLV | ||
| 9/24/2022 | Indianapolis (9-2) | 44 | at | Ohio Dominican | 38 | GLV | ||
| 10/1/2022 | Walsh (1-9,1-7) | 0 | at | Ohio Dominican | 21 | |||
| 10/8/2022 | Ohio Dominican | 38 | at | Lake Erie (3-8,3-5) | 7 | |||
| 10/15/2022 | Ohio Dominican | 7 | at | Ashland (10-2,7-1) | 14 | |||
| 10/22/2022 | Kentucky Wesleyan (2-9,1-7) | 7 | at | Ohio Dominican | 49 | |||
| 11/5/2022 | Ohio Dominican | 35 | at | Northwood (3-8,2-6) | 24 | |||
| 11/12/2022 | Hillsdale (5-6,4-4) | 10 | at | Ohio Dominican | 20 |
| vs Ohio Dominican | vs Other Opponents | Ohio Dominican compared to OOs | |
| Record: | 3-7 | 45-55 | |
| Points Scored: | 16.90 | 24.99 | 8.09 |
| Points Allowed: | 28.00 | 27.08 | 0.92 |
| Margin: | -11.10 | -2.09 | 9.01 |
| Total Points: | 44.90 | 52.07 | -7.17 |