| 9/3/2022 | Hillsdale (5-6,4-4) | 35 | at | Lake Erie | 31 | |||
| 9/10/2022 | Lake Erie | 26 | at | Kentucky Wesleyan (2-9,1-7) | 21 | |||
| 9/17/2022 | McKendree (5-6) | 38 | at | Lake Erie | 37 | GLV | ||
| 9/24/2022 | Lake Erie | 31 | at | Southwest Baptist (6-5) | 52 | at GLV | ||
| 10/1/2022 | Lake Erie | 27 | at | Tiffin (6-5,6-2) | 52 | |||
| 10/8/2022 | Ohio Dominican (7-3,6-2) | 38 | at | Lake Erie | 7 | |||
| 10/15/2022 | Lake Erie | 22 | at | Walsh (1-9,1-7) | 15 | OT | ||
| 10/22/2022 | Northwood (3-8,2-6) | 18 | at | Lake Erie | 21 | |||
| 10/29/2022 | Lake Erie | 17 | at | Findlay (7-4,6-2) | 42 | |||
| 11/5/2022 | Ashland (10-2,7-1) | 31 | at | Lake Erie | 23 | |||
| 11/12/2022 | Northern Michigan (4-7) | 33 | at | Lake Erie | 11 | GLIAC |
| vs Lake Erie | vs Other Opponents | Lake Erie compared to OOs | |
| Record: | 8-3 | 48-61 | |
| Points Scored: | 34.09 | 24.78 | -9.31 |
| Points Allowed: | 23.00 | 27.31 | -4.31 |
| Margin: | 11.09 | -2.53 | -13.62 |
| Total Points: | 57.09 | 52.09 | 5.00 |