| 9/1/2022 | Central Missouri (4-7,4-7) | 10 | at | Pittsburg State | 21 | | | |
| 9/8/2022 | Pittsburg State | 35 | at | Nebraska-Kearney (8-3,8-3) | 28 | | | |
| 9/17/2022 | Northeastern State (1-10,1-10) | 14 | at | Pittsburg State | 49 | | | |
| 9/24/2022 | Pittsburg State | 14 | at | Emporia State (9-3,8-3) | 13 | | | |
| 10/1/2022 | Missouri Southern (4-7,4-7) | 9 | at | Pittsburg State | 38 | | | |
| 10/8/2022 | Northwest Missouri State (10-3,9-2) | 22 | at | Pittsburg State | 24 | | | |
| 10/15/2022 | Pittsburg State | 49 | at | Lincoln MO (0-11,0-11) | 10 | | | |
| 10/22/2022 | Missouri Western (5-6,5-6) | 16 | at | Pittsburg State | 28 | | | |
| 10/29/2022 | Pittsburg State | 38 | at | Central Oklahoma (6-5,6-5) | 7 | | | |
| 11/5/2022 | Pittsburg State | 37 | at | Washburn (7-4,7-4) | 23 | | | |
| 11/12/2022 | Fort Hays State (3-8,3-8) | 14 | at | Pittsburg State | 35 | | | |
| 11/19/2022 | Indianapolis (9-2) | 0 | at | Pittsburg State | 35 | | D2 Championship Round 1 | GLV |
| 11/26/2022 | Pittsburg State | 14 | at | Ferris State (14-1) | 17 | | D2 Playoffs Round 2 | at GLIAC |