| 9/3/2022 | Warner U. (0-8) | 3 | at | West Florida | 52 | Sun (NAIA) | ||
| 9/10/2022 | West Florida | 49 | at | Southwest Baptist (6-5) | 10 | at GLV | ||
| 9/24/2022 | Delta State (11-2,7-2) | 45 | at | West Florida | 42 | 2OT | ||
| 10/1/2022 | North Greenville (3-8,2-6) | 31 | at | West Florida | 34 | |||
| 10/8/2022 | West Florida | 42 | at | West Georgia (8-2,6-2) | 28 | |||
| 10/15/2022 | West Florida | 50 | at | Shorter (3-8,1-7) | 26 | |||
| 10/22/2022 | Mississippi College (4-7,3-5) | 17 | at | West Florida | 45 | |||
| 10/29/2022 | West Alabama (5-6,3-5) | 24 | at | West Florida | 36 | |||
| 11/5/2022 | West Florida | 32 | at | Valdosta State (5-6,3-5) | 31 | OT | ||
| 11/12/2022 | West Florida | 56 | at | Mississippi College (4-7,3-5) | 21 | |||
| 11/19/2022 | Limestone (8-4) | 19 | at | West Florida | 45 | D2 Championship Round 1 | SAC | |
| 11/26/2022 | West Florida | 38 | at | Delta State (11-2,7-2) | 27 | D2 Playoffs Round 2 | ||
| 12/3/2022 | Wingate (11-3) | 14 | at | West Florida | 45 | D2 Quarterfinals | SAC | |
| 12/10/2022 | West Florida | 17 | at | Ferris State (14-1) | 38 | D2 Semifinal | at GLIAC |
| vs West Florida | vs Other Opponents | West Florida compared to OOs | |
| Record: | 2-12 | 90-54 | |
| Points Scored: | 23.86 | 32.34 | 8.48 |
| Points Allowed: | 41.64 | 27.64 | 14.00 |
| Margin: | -17.78 | 4.70 | 22.48 |
| Total Points: | 65.50 | 59.98 | 5.52 |