| 9/3/2022 | Hillsdale | 35 | at | Lake Erie (3-8,3-5) | 31 | |||
| 9/10/2022 | Walsh (1-9,1-7) | 17 | at | Hillsdale | 35 | |||
| 9/17/2022 | Truman State (9-2) | 21 | at | Hillsdale | 13 | GLV | ||
| 9/24/2022 | Hillsdale | 17 | at | Missouri S&T (3-7) | 10 | at GLV | ||
| 10/1/2022 | Hillsdale | 27 | at | Kentucky Wesleyan (2-9,1-7) | 31 | |||
| 10/8/2022 | Tiffin (6-5,6-2) | 41 | at | Hillsdale | 0 | |||
| 10/15/2022 | Hillsdale | 41 | at | Northwood (3-8,2-6) | 7 | |||
| 10/22/2022 | Findlay (7-4,6-2) | 41 | at | Hillsdale | 20 | |||
| 10/29/2022 | Ashland (10-2,7-1) | 20 | at | Hillsdale | 36 | |||
| 11/5/2022 | Michigan Tech (4-7) | 28 | at | Hillsdale | 24 | GLIAC | ||
| 11/12/2022 | Hillsdale | 10 | at | Ohio Dominican (7-3,6-2) | 20 |
| vs Hillsdale | vs Other Opponents | Hillsdale compared to OOs | |
| Record: | 6-5 | 49-59 | |
| Points Scored: | 24.27 | 24.18 | -0.09 |
| Points Allowed: | 23.45 | 25.62 | -2.17 |
| Margin: | 0.82 | -1.44 | -2.26 |
| Total Points: | 47.72 | 49.80 | -2.08 |