| 9/3/2022 | Kentucky Wesleyan | 13 | at | Northwood (3-8,2-6) | 55 | |||
| 9/10/2022 | Lake Erie (3-8,3-5) | 26 | at | Kentucky Wesleyan | 21 | |||
| 9/17/2022 | Missouri S&T (3-7) | 6 | at | Kentucky Wesleyan | 11 | GLV | ||
| 9/24/2022 | Kentucky Wesleyan | 17 | at | William Jewell (2-9) | 24 | at GLV | ||
| 10/1/2022 | Hillsdale (5-6,4-4) | 27 | at | Kentucky Wesleyan | 31 | |||
| 10/8/2022 | Kentucky Wesleyan | 9 | at | Quincy (4-7) | 46 | at GLV | ||
| 10/15/2022 | Findlay (7-4,6-2) | 44 | at | Kentucky Wesleyan | 7 | |||
| 10/22/2022 | Kentucky Wesleyan | 7 | at | Ohio Dominican (7-3,6-2) | 49 | |||
| 10/29/2022 | Kentucky Wesleyan | 10 | at | Walsh (1-9,1-7) | 35 | |||
| 11/5/2022 | Tiffin (6-5,6-2) | 72 | at | Kentucky Wesleyan | 13 | |||
| 11/12/2022 | Kentucky Wesleyan | 10 | at | Ashland (10-2,7-1) | 41 |
| vs Kentucky Wesleyan | vs Other Opponents | Kentucky Wesleyan compared to OOs | |
| Record: | 9-2 | 42-66 | |
| Points Scored: | 38.64 | 23.44 | -15.20 |
| Points Allowed: | 13.55 | 27.54 | -13.99 |
| Margin: | 25.09 | -4.10 | -29.19 |
| Total Points: | 52.19 | 50.98 | 1.21 |