| 9/1/2022 | Colorado Mesa | 37 | at | William Jewell (2-9) | 14 | at GLV | ||
| 9/17/2022 | South Dakota Tech (7-4,6-3) | 31 | at | Colorado Mesa | 17 | |||
| 9/24/2022 | Colorado Mesa | 28 | at | Black Hills State (7-4,5-4) | 31 | |||
| 10/1/2022 | Western Colorado (7-4,7-2) | 42 | at | Colorado Mesa | 34 | 2OT | ||
| 10/8/2022 | Colorado Mesa | 21 | at | Colorado Mines (13-3,10-0) | 48 | |||
| 10/15/2022 | Fort Lewis (0-10,0-9) | 10 | at | Colorado Mesa | 70 | |||
| 10/22/2022 | Colorado Mesa | 31 | at | Adams State (2-9,2-7) | 45 | |||
| 10/29/2022 | Colorado State-Pueblo (8-4,7-3) | 33 | at | Colorado Mesa | 28 | |||
| 11/5/2022 | Colorado Mesa | 38 | at | Chadron State (3-8,3-6) | 37 | OT | ||
| 11/12/2022 | New Mexico Highlands (3-7,3-6) | 36 | at | Colorado Mesa | 56 |
| vs Colorado Mesa | vs Other Opponents | Colorado Mesa compared to OOs | |
| Record: | 6-4 | 46-58 | |
| Points Scored: | 32.70 | 26.88 | -5.82 |
| Points Allowed: | 36.00 | 29.89 | 6.11 |
| Margin: | -3.30 | -3.01 | 0.29 |
| Total Points: | 68.70 | 56.77 | 11.93 |