| 9/1/2022 | South Dakota Tech | 43 | at | Missouri S&T (3-7) | 20 | at GLV | ||
| 9/10/2022 | Truman State (9-2) | 27 | at | South Dakota Tech | 20 | GLV | ||
| 9/17/2022 | South Dakota Tech | 31 | at | Colorado Mesa (4-6,3-6) | 17 | |||
| 9/24/2022 | New Mexico Highlands (3-7,3-6) | 27 | at | South Dakota Tech | 41 | |||
| 10/1/2022 | Black Hills State (7-4,5-4) | 24 | at | South Dakota Tech | 17 | |||
| 10/8/2022 | South Dakota Tech | 38 | at | Western Colorado (7-4,7-2) | 10 | |||
| 10/15/2022 | Colorado Mines (13-3,10-0) | 48 | at | South Dakota Tech | 20 | |||
| 10/22/2022 | South Dakota Tech | 65 | at | Fort Lewis (0-10,0-9) | 20 | |||
| 10/29/2022 | Adams State (2-9,2-7) | 20 | at | South Dakota Tech | 23 | |||
| 11/5/2022 | South Dakota Tech | 20 | at | Colorado State-Pueblo (8-4,7-3) | 45 | |||
| 11/12/2022 | Chadron State (3-8,3-6) | 7 | at | South Dakota Tech | 28 |
| vs South Dakota Tech | vs Other Opponents | South Dakota Tech compared to OOs | |
| Record: | 4-7 | 55-57 | |
| Points Scored: | 24.09 | 28.67 | 4.58 |
| Points Allowed: | 31.45 | 28.96 | 2.49 |
| Margin: | -7.36 | -0.29 | 7.07 |
| Total Points: | 55.54 | 57.63 | -2.09 |