| 9/1/2016 | Indiana | 34 | at | Florida Intl | 13 | @ CUSA | ||
| Oregon State | 23 | at | Minnesota | 30 | P12 | |||
| 9/2/2016 | Furman | 13 | at | Michigan State | 28 | SoCon (1AA) | ||
| 9/3/2016 | Murray State | 3 | at | Illinois | 52 | OVC (1AA) | ||
| Miami-Ohio | 21 | at | Iowa | 45 | MAC | |||
| Howard | 13 | at | Maryland | 52 | MEAC (1AA) | |||
| Hawaii | 3 | at | Michigan | 63 | MW | |||
| Fresno State | 10 | at | Nebraska | 43 | MW | |||
| Western Michigan | 22 | at | Northwestern | 21 | MAC | |||
| Bowling Green | 10 | at | Ohio State | 77 | MAC | |||
| Kent State | 13 | at | Penn State | 33 | MAC | |||
| Eastern Kentucky | 24 | at | Purdue | 45 | OVC (1AA) | |||
| Rutgers | 13 | at | Washington | 48 | @ P12 | |||
| LSU | 14 | vs | Wisconsin | 16 | Green Bay WI | vs SEC | ||
| 9/9/2016 | Maryland | 41 | at | Florida Intl | 14 | @ CUSA | ||
| 9/10/2016 | North Carolina | 48 | at | Illinois | 23 | ACC | ||
| Ball State | 20 | at | Indiana | 30 | MAC | |||
| Iowa State | 3 | at | Iowa | 42 | B12 | |||
| UCF | 14 | at | Michigan | 51 | AAC | |||
| Indiana State | 28 | at | Minnesota | 58 | MVC (1AA) | |||
| Wyoming | 17 | at | Nebraska | 52 | MW | |||
| Illinois State | 9 | at | Northwestern | 7 | MVC (1AA) | |||
| Tulsa | 3 | at | Ohio State | 48 | AAC | |||
| Penn State | 39 | at | Pittsburgh | 42 | @ ACC | |||
| Cincinnati | 38 | at | Purdue | 20 | AAC | |||
| Howard | 14 | at | Rutgers | 52 | MEAC (1AA) | |||
| Akron | 10 | at | Wisconsin | 54 | MAC | |||
| 9/17/2016 | Maryland | 30 | at | UCF | 24 | @ AAC | ||
| Western Michigan | 34 | at | Illinois | 10 | MAC | |||
| North Dakota State | 23 | at | Iowa | 21 | MVC (1AA) | |||
| Colorado | 28 | at | Michigan | 45 | P12 | |||
| Oregon | 32 | at | Nebraska | 35 | P12 | |||
| Duke | 13 | at | Northwestern | 24 | ACC | |||
| Michigan State | 36 | at | Notre Dame | 28 | @ ND | |||
| Ohio State | 45 | at | Oklahoma | 24 | @ B12 | |||
| Temple | 27 | at | Penn State | 34 | AAC | |||
| New Mexico | 28 | at | Rutgers | 37 | MW | |||
| Georgia State | 17 | at | Wisconsin | 23 | SBC | |||
| 9/24/2016 | Wake Forest | 33 | at | Indiana | 28 | ACC | ||
| Penn State | 10 | at | Michigan | 49 | ||||
| Wisconsin | 30 | at | Michigan State | 6 | ||||
| Colorado State | 24 | at | Minnesota | 31 | MW | |||
| Nebraska | 24 | at | Northwestern | 13 | ||||
| Nevada | 14 | at | Purdue | 24 | MW | |||
| Iowa | 14 | at | Rutgers | 7 | ||||
| 10/1/2016 | Michigan State | 21 | at | Indiana | 24 | OT | ||
| Northwestern | 38 | at | Iowa | 31 | ||||
| Purdue | 7 | at | Maryland | 50 | ||||
| Wisconsin | 7 | at | Michigan | 14 | ||||
| Illinois | 16 | at | Nebraska | 31 | ||||
| Rutgers | 0 | at | Ohio State | 58 | ||||
| Minnesota | 26 | at | Penn State | 29 | OT | |||
| 10/8/2016 | Purdue | 34 | at | Illinois | 31 | OT | ||
| BYU | 31 | at | Michigan State | 14 | Ind | |||
| Iowa | 14 | at | Minnesota | 7 | ||||
| Indiana | 17 | at | Ohio State | 38 | ||||
| Maryland | 14 | at | Penn State | 38 | ||||
| Michigan | 78 | at | Rutgers | 0 | ||||
| 10/15/2016 | Nebraska | 27 | at | Indiana | 22 | |||
| Minnesota | 31 | at | Maryland | 10 | ||||
| Northwestern | 54 | at | Michigan State | 40 | ||||
| Iowa | 49 | at | Purdue | 35 | ||||
| Illinois | 24 | at | Rutgers | 7 | ||||
| Ohio State | 30 | at | Wisconsin | 23 | OT | |||
| 10/22/2016 | Wisconsin | 17 | at | Iowa | 9 | |||
| Michigan State | 17 | at | Maryland | 28 | ||||
| Illinois | 8 | at | Michigan | 41 | ||||
| Rutgers | 32 | at | Minnesota | 34 | ||||
| Purdue | 14 | at | Nebraska | 27 | ||||
| Indiana | 14 | at | Northwestern | 24 | ||||
| Ohio State | 21 | at | Penn State | 24 | ||||
| 10/29/2016 | Minnesota | 40 | at | Illinois | 17 | |||
| Maryland | 36 | at | Indiana | 42 | ||||
| Michigan | 32 | at | Michigan State | 23 | ||||
| Northwestern | 20 | at | Ohio State | 24 | ||||
| Penn State | 62 | at | Purdue | 24 | ||||
| Nebraska | 17 | at | Wisconsin | 23 | OT | |||
| 11/5/2016 | Michigan State | 27 | at | Illinois | 31 | |||
| Maryland | 3 | at | Michigan | 59 | ||||
| Purdue | 31 | at | Minnesota | 44 | ||||
| Wisconsin | 21 | at | Northwestern | 7 | ||||
| Nebraska | 3 | at | Ohio State | 62 | ||||
| Iowa | 14 | at | Penn State | 41 | ||||
| Indiana | 33 | at | Rutgers | 27 | ||||
| 11/12/2016 | Penn State | 45 | at | Indiana | 31 | |||
| Michigan | 13 | at | Iowa | 14 | ||||
| Ohio State | 62 | at | Maryland | 3 | ||||
| Rutgers | 0 | at | Michigan State | 49 | ||||
| Minnesota | 17 | at | Nebraska | 24 | ||||
| Northwestern | 45 | at | Purdue | 17 | ||||
| Illinois | 3 | at | Wisconsin | 48 | ||||
| 11/19/2016 | Iowa | 28 | at | Illinois | 0 | |||
| Indiana | 10 | at | Michigan | 20 | ||||
| Ohio State | 17 | at | Michigan State | 16 | ||||
| Northwestern | 12 | at | Minnesota | 29 | ||||
| Maryland | 7 | at | Nebraska | 28 | ||||
| Wisconsin | 49 | at | Purdue | 20 | ||||
| Penn State | 39 | at | Rutgers | 0 | ||||
| 11/25/2016 | Nebraska | 10 | at | Iowa | 40 | |||
| 11/26/2016 | Purdue | 24 | at | Indiana | 26 | |||
| Rutgers | 13 | at | Maryland | 31 | ||||
| Illinois | 21 | at | Northwestern | 42 | ||||
| Michigan | 27 | at | Ohio State | 30 | 2OT | |||
| Michigan State | 12 | at | Penn State | 45 | ||||
| Minnesota | 17 | at | Wisconsin | 31 | ||||
| 12/3/2016 | Wisconsin | 31 | vs | Penn State | 38 | Indianapolis IN | ||
| 12/26/2016 | Maryland | 30 | vs | Boston College | 36 | Quick Lane Bowl (Detroit MI) | vs ACC | |
| 12/27/2016 | Minnesota | 17 | vs | Washington State | 12 | Holiday Bowl (San Diego CA) | vs P12 | |
| 12/28/2016 | Pittsburgh | 24 | vs | Northwestern | 31 | Pinstripe Bowl (New York NY) | vs ACC | |
| Indiana | 24 | vs | Utah | 26 | Foster Farms Bowl (Santa Clara CA) | vs P12 | ||
| 12/30/2016 | Michigan | 32 | vs | Florida State | 33 | Orange Bowl (Miami FL) | vs ACC | |
| Nebraska | 24 | vs | Tennessee | 38 | Music City Bowl (Nashville TN) | vs SEC | ||
| 12/31/2016 | Ohio State | 0 | vs | Clemson | 31 | Fiesta Bowl (Glendale AZ -1A Semifinal) | vs ACC | |
| 1/2/2017 | Florida | 30 | vs | Iowa | 3 | Outback Bowl (Tampa FL) | vs SEC | |
| Southern California | 52 | vs | Penn State | 49 | Rose Bowl (Pasadena CA) | vs P12 | ||
| Western Michigan | 16 | vs | Wisconsin | 24 | Cotton Bowl (Dallas TX) | vs MAC |